منابع مشابه
Cellular senescence and the aging brain.
Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with age in a variety of human and mouse tissues where they express a complex 'senescence-associated secretory phenotype' (SASP). The SASP includes many pro-inflammatory cytokines, chemokines, growth factors and prote...
متن کاملAging, cellular senescence, and cancer.
For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging also promotes hyperplastic pathologies, the most deadly of which is cancer. In contrast to the loss of function that characterizes degenerating cells and tissues, malignant (cancerous) cells must acquire ne...
متن کاملCellular Aging: Symmetry Evades Senescence
Cellular aging programs typically rely on the asymmetric shape and growth pattern of cells. A new study shows that symmetric fission yeast cells escape classic signs of aging until they encounter environmental stress.
متن کاملCellular senescence in aging primates.
The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a r...
متن کاملFat tissue, aging, and cellular senescence
Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is associated with accelerated onset of diseases common in old age, while fat ablation and certain mutations affecting fat increase life span. Fat cells turn over throughout the l...
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ژورنال
عنوان ژورنال: Experimental Gerontology
سال: 2015
ISSN: 0531-5565
DOI: 10.1016/j.exger.2014.09.018